WHO WE ARE

Stellate Therapeutics

Stellate Therapeutics is an international biotech company with locations in Paris, France and NYC, USA

Stellate Therapeutics

Stellate Therapeutics is an international biotech company with locations in:

Paris, France and NYC, USA

Microbiome-derived

medicine technology platform for discovery and de-risked development of personalized medicines

Focus on CNS diseases

with most advanced projects in Parkinson’s and Alzheimer’s disease

Strong IP

and an industry-leading, international team, including world experts in microbiology

A pipeline

of 5 product candidates for partnership and joint development

Expansion of technology

platform across neurological diseases and potentially into other indications

Harness the gut-brain axis to

change the trajectory of brain diseases

Bacteria have co-evolved with humans and have become critical to maintaining our health

 

Recent studies have shown that our gut microbiome impacts brain diseases

 

Microbiome-made molecules are an ideal source for potential new treatments because they are endogenous and therefore less likely to be toxic

Stellate’s microbiome-derived medicine platform leverages trillions of human gut bacteria to:

Identify

efficacious therapies that have a lower risk for adverse reactions

Select

responsive patients early in the process to de-risk development

Treat

disease-modifying medicines that improve patients’ lives

About Us

Stellate Therapeutics is an international biotechnology company

with locations in Paris, France and NYC, USA focused on the use of small molecules to
treat neurodegenerative disorders. Through millions of years of co-evolution, humans
have developed a symbiotic relationship with our microbiome. Metabolites that our
microbiome generate contribute to homeostasis, health and wellbeing. By exploring the
interaction and function of these molecules in disease states, Stellate hopes to develop
therapeutics that address unmet needs in a number of neurological conditions. Our lead
candidate STL-101 is in the preclinical stage of development

for treatment of Parkinson’s disease.

Team

After studying finance at Dauphine and HEC (École des Hautes Etudes Commerciales), Sophie began her career in investment banking, including four years in the biotechnology sector at Bryan, Garnier, and Kepler. As a result, she worked for biotechnology companies in various therapeutic areas, executing many deals, including IPOs (BioAlliance Pharma, Medicrea), capital increases (Transgene), block trades (Stedim), private placements (Trophos), as well as mergers and acquisitions. Passionate about the healthcare sector, Sophie then founded her own consulting firm in the field of healthcare, Life Sciences Conseil, in order to help biotech start-ups raise capital with investors (venture capital funds, seed money, business angels, etc.) as well as advise venture capital funds on their investments in biotech start-ups.

She also co-founded the Microbiome Foundation which is a French non-profit organization financing cutting-edge research on the gut microbiota in connection with chronic diseases as well as raising public awareness about the critical role of nutrition in shaping the microbiota and preserving one’s “health capital”. The Microbiome Foundation was launched, in the context of rising chronic diseases, out of a desire to contribute to a major scientific revolution in promoting a new paradigm in healthcare, towards a more personalised and preventative approach of healthcare.

SOPHIE DURAND

CEO

Dr. Immke is a scientific leader who brings deep industry and neuroscience expertise to Stellate Therapeutics. David has an impressive track record of advancing novel agents into clinical trials across multiple modalities against innovative targets in Neurology, Psychiatry, Chronic Pain and Migraine. Prior to joining Stellate as Chief Scientific Officer David spent 17 years at Amgen culminating as Head of Neuroscience Research, Vice President of R&D Transformation and the Scientific Lead for Aimovig, a first in class CGRP receptor antibody for Migraine Prophylaxis.

By training he is an electrophysiologist with an expertise in ion channel structure-function who studied at the University of Connecticut Dept of Physiology and Neurobiology (PhD) and the Vollum institute for Advanced Biomolecular Research (post-doctoral fellowship) in Portland Oregon. David also has clinical research experience in Bone Metabolism from the Osteoporosis Center at the University of Connecticut Health Center and performed Cardiovascular Physiology research for his BS/MS from Eastern Illinois University. David has received Outstanding Alumni awards from both EIU and Univ of Connecticut.

DAVID IMMKE

CSO

Dr. Weiss is spearheading business development operations at Stellate Therapeutics by helping to plan and coordinate collaborations and partnerships with academic labs, CRO’s, CMO’s, biopharmaceutical companies and Venture Capital firms.

Jonathan was most recently a scientist Kadmon Pharmaceuticals, leading multiple drug development projects. There he developed the drug Belumosudil for Chronic Graft Versus Host Disease (cGVHD), which was granted Breakthrough and Orphan Drug designations by the FDA, was allowed to bypass a Phase III Clinical Trial and is currently under review by the FDA. He has over 15 years of research experience focusing on Immune Tolerance and Neuroregeneration in both basic science research and drug development.

He has trained at Binghamton University (BS), The NYU School of Medicine (PhD) and The NYU Stern School of Business (MBA). Jonathan has interned for the NYU Office of Industrial Liaison, consulted Pfizer on models of external innovation, and consulted both diagnostic and therapeutics companies.

JONATHAN WEISS

Director, Business Dev.

Dr. Richard is a molecular and cellular biologist with a long-standing interest in RNA biology and understanding neurodegeneration. During her postdoctoral studies, and as an associate research scientist at Columbia University, she focused her efforts towards elucidating the molecular role of Senataxin, a protein mutated in two neurological disorders, a juvenile form of ALS (amyotrophic lateral sclerosis, ALS4) and a form of ataxia (Ataxia with Oculomotor Apraxia Type 2, AOA2). In 2019, she joined Stellate Therapeutics as program director at the JLABS location in NYC. Now, Director of Neuroscience, she leads and manages pre-clinical neuroscience programs including but not limited to Parkinson’s disease. She’s also in charge of grant writing and has successfully received funding for her academic research valued at over $700,000. Her long-term goal is to be part of the collaborative effort that enables the development of therapeutics to fight neurodegeneration.

PATRICIA RICHARD

Director, Neuroscience

Dr. Manière is the Director of discovery biology. He holds a PharmD (Université de Lorraine) and PhD (Université de Paris). During his PhD at the UFR Médecine Paris Centre he studied the role of gut bacteria in aging trajectories. He then joined the Laboratoires Servier where he led projects at the preclinical stage in the therapeutic fields of neurology, oncology and metabolism. He has been the director of discovery biology at Stellate Therapeutics since 2016.

XAVIER MANIERE

Director, Discovery

Dr. Stukes is a trained scientist specializing in infectious diseases and host pathogen interactions. She holds a PhD in Biomedical Sciences from the Albert Einstein College of Medicine and has held positions at both the New York University Grossman School of Medicine and The National Institute of Allergies and Infectious Diseases. Prior to joining Stellate, she was the founding Assistant Director for the Master's in Translational Medicine (MTM) at City University of New York, a brand new type of graduate degree that educates and trains scientists and engineers in the hands-on process of medical technology commercialization and healthcare innovation. She also holds a Biomedical Engineering teaching position at the Grove School of Engineering, City College of New York

SABRIYA STUKES

Operations Director

Board of Directors and Scientific Advisors

patrice-garnier

PATRICE GARNIER

Chairman
antoine-danchin

antoine danchin

Scientific Founder
robert-schneider

robert schneider

Strategic Advisor
bernard-munos

Bernard Munos

Strategic Advisor
eric

Eric Fourmentin

Strategic Advisor
alexandre-mouradian

ALEX MOURADIAN

Strategic Advisor

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Michael Spedding

Scientific Advisor
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Sahar El Aidy

Scientific Advisor
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Geraldine Androdias

Scientific Advisor